Titia K. Sixma : rechercher sur Z-Library

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ATP Increases the Affinity between MutS ATPase Domains

Lamers, Meindert H., Georgijevic, Dubravka, Lebbink, Joyce H., Winterwerp, Herrie H. K., Agianian, Bogos, de Wind, Niels, Sixma, Titia K.

Journal:

Journal of Biological Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 800 KB

english, 2004

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

Kim, Robbert Q., Geurink, Paul P., Mulder, Monique P. C., Fish, Alexander, Ekkebus, Reggy, El Oualid, Farid, van Dijk, Willem J., van Dalen, Duco, Ovaa, Huib, van Ingen, Hugo, Sixma, Titia K.

Journal:

Nature Communications

Année:

2019

Langue:

english

Fichier:

PDF, 2.22 MB

english, 2019

Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin

Dr. Farid El Oualid, Dr. Remco Merkx, Reggy Ekkebus, Dharjath S. Hameed, Judith J. Smit, Annemieke de Jong, Henk Hilkmann, Prof. Dr. Titia K. Sixma, Dr. Huib Ovaa

Journal:

Angewandte Chemie

Année:

2010

Langue:

english

Fichier:

PDF, 507 KB

english, 2010

Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin

Dr. Farid El Oualid, Dr. Remco Merkx, Reggy Ekkebus, Dharjath S. Hameed, Judith J. Smit, Annemieke de Jong, Henk Hilkmann, Prof. Dr. Titia K. Sixma, Dr. Huib Ovaa

Journal:

Angewandte Chemie International Edition

Année:

2010

Langue:

english

Fichier:

PDF, 542 KB

english, 2010

Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT)

Ethan A. Merritt, Titia K. Sixma, Kor H. Kalk, Ben A. M. van Zanten, Wim G. J. Hol

Journal:

Molecular Microbiology

Année:

1994

Langue:

english

Fichier:

PDF, 3.61 MB

english, 1994

Interaction of α-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor

Igor E. Kasheverov, Maxim N. Zhmak, Alexander Fish, Prakash Rucktooa, Alexey Yu. Khruschov, Alexey V. Osipov, Rustam H. Ziganshin, Dieter D’hoedt, Daniel Bertrand, Titia K. Sixma, August B. Smit, Vict

Journal:

Journal of Neurochemistry

Année:

2009

Langue:

english

Fichier:

PDF, 723 KB

english, 2009

10.1038/35037523

Sixma, Titia K., Lamers, Meindert H., Perrakis, Anastassis, Enzlin, Jacqueline H., Winterwerp, Herrie H. K., de Wind, Niels

Journal:

Nature

Année:

2000

Langue:

english

Fichier:

PDF, 687 KB

english, 2000

10.1038/35077011

Brejc, Katjua, van Dijk, Willem J., Klaassen, Remco V., Schuurmans, Mascha, van der Oost, John, Smit, August B., Sixma, Titia K.

Journal:

Nature

Année:

2001

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2001

Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli

Sixma, Titia K., Pronk, Sylvia E., Kalk, Kor H., Wartna, Ellen S., van Zanten, Ben A. M., Witholt, Bernard, Hoi, Wim G. J.

Journal:

Nature

Année:

1991

Fichier:

PDF, 869 KB

1991

Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography

Hol, Wim G. J., Sixma, Titia K., Pronk, SyMa E., Kalk, Kor H., van Zanten, Ben A. M., Berghuis, Albert M.

Journal:

Nature

Année:

1992

Fichier:

PDF, 720 KB

1992

Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain

Luna-Vargas, Mark P A, Faesen, Alex C, van Dijk, Willem J, Rape, Michael, Fish, Alexander, Sixma, Titia K

Journal:

EMBO reports

Année:

2011

Langue:

english

Fichier:

PDF, 1.24 MB

english, 2011

Nicotinic receptor structure emerging slowly

Sixma, Titia K

Journal:

Nature Neuroscience

Année:

2007

Langue:

english

Fichier:

PDF, 249 KB

english, 2007

Divide and conquer: the E2 active site

Knipscheer, Puck, Sixma, Titia K

Journal:

Nature Structural and Molecular Biology

Année:

2006

Langue:

english

Fichier:

PDF, 267 KB

english, 2006

The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type

Pichler, Andrea, Knipscheer, Puck, Saitoh, Hisato, Sixma, Titia K, Melchior, Frauke

Journal:

Nature Structural and Molecular Biology

Année:

2004

Langue:

english

Fichier:

PDF, 1.22 MB

english, 2004

SUMO modification of the ubiquitin-conjugating enzyme E2-25K

Pichler, Andrea, Knipscheer, Puck, Oberhofer, Edith, van Dijk, Willem J, Körner, Roman, Olsen, Jesper Velgaard, Jentsch, Stefan, Melchior, Frauke, Sixma, Titia K

Journal:

Nature Structural and Molecular Biology

Année:

2005

Langue:

english

Fichier:

PDF, 500 KB

english, 2005

Dual role of MutS glutamate 38 in DNA mismatch discrimination and in the authorization of repair

Lebbink, Joyce H G, Georgijevic, Dubravka, Natrajan, Ganesh, Fish, Alexander, Winterwerp, Herrie H K, Sixma, Titia K, de Wind, Niels

Journal:

The EMBO Journal

Année:

2006

Langue:

english

Fichier:

PDF, 418 KB

english, 2006

Structure and E3-ligase activity of the Ring–Ring complex of Polycomb proteins Bmi1 and Ring1b

Buchwald, Gretel, van der Stoop, Petra, Weichenrieder, Oliver, Perrakis, Anastassis, van Lohuizen, Maarten, Sixma, Titia K

Journal:

The EMBO Journal

Année:

2006

Langue:

english

Fichier:

PDF, 431 KB

english, 2006

Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation

Knipscheer, Puck, van Dijk, Willem J, Olsen, Jesper V, Mann, Matthias, Sixma, Titia K

Journal:

The EMBO Journal

Année:

2007

Langue:

english

Fichier:

PDF, 409 KB

english, 2007

Structure and Function of AChBP, Homologue of the Ligand-Binding Domain of the Nicotinic Acetylcholine Receptor

AUGUST B. SMIT, KATJUŠA BREJC, NAWEED SYED, TITIA K. SIXMA

Journal:

Annals of the New York Academy of Sciences

Année:

2003

Fichier:

PDF, 6.35 MB

2003

Acetylcholine-binding proteins

August B. Smit, Patrick H. N. Celie, Igor E. Kasheverov, Dmitry Y. Mordvintsev, Pim van Nierop, Daniel Bertrand, Victor Tsetlin, Titia K. Sixma

Journal:

Journal of Molecular Neuroscience

Année:

2006

Langue:

english

Fichier:

PDF, 55 KB

english, 2006

The role of UBL domains in ubiquitin-specific proteases

Faesen, Alex C., Luna‑Vargas, Mark P.A., Sixma, Titia K.

Journal:

Biochemical Society Transactions

Année:

2012

Langue:

english

Fichier:

PDF, 689 KB

english, 2012

Differences in permeability of dioleoylphosphatidylcholine model membranes containing saturated or unsaturated phosphatidic acids

Erik B. Smaal, Titia K. Sixma, Jacqueline G. Mandersloot, Johannes De Gier

Journal:

Bioelectrochemistry and Bioenergetics

Année:

1986

Langue:

english

Fichier:

PDF, 365 KB

english, 1986

Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA

van Pouderoyen, Gertie, Ketting, René F., Perrakis, Anastassis, Plasterk, Ronald H.A., Sixma, Titia K.

Journal:

The EMBO Journal

Année:

1997

Langue:

english

Fichier:

PDF, 700 KB

english, 1997

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

Mattiroli, Francesca, Cui, Gaofeng, Young, Leah C, Hendzel, Michael J, Mer, Georges, Sixma, Titia K, Richard, Stéphane, Mallette, Frédérick A

Journal:

The EMBO Journal

Année:

2012

Langue:

english

Fichier:

PDF, 2.89 MB

english, 2012

ACETYLCHOLINE BINDING PROTEIN (AChBP): A Secreted Glial Protein That Provides a High-Resolution Model for the Extracellular Domain of Pentameric Ligand-Gated Ion Channels

Sixma, Titia K., Smit, August B.

Journal:

Annual Review of Biophysics and Biomolecular Structure

Année:

2003

Langue:

english

Fichier:

PDF, 860 KB

english, 2003

Insight in nAChR subtype selectivity from AChBP crystal structures

Prakash Rucktooa, August B. Smit, Titia K. Sixma

Journal:

Biochemical Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2009

Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors

Atilla Akdemir, Prakash Rucktooa, Aldo Jongejan, Rene van Elk, Sonia Bertrand, Titia K. Sixma, Daniel Bertrand, August B. Smit, Rob Leurs, Chris de Graaf, Iwan J.P. de Esch

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1022 KB

english, 2011

The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types

Alex C. Faesen, Mark P.A. Luna-Vargas, Paul P. Geurink, Marcello Clerici, Remco Merkx, Willem J. van Dijk, Dharjath S. Hameed, Farid El Oualid, Huib Ovaa, Titia K. Sixma

Journal:

Chemistry & Biology

Année:

2011

Langue:

english

Fichier:

PDF, 1.68 MB

english, 2011

Structural aspects of multi-domain RING/Ubox E3 ligases in DNA repair

Richard G. Hibbert, Francesca Mattiroli, Titia K. Sixma

Journal:

DNA Repair

Année:

2009

Langue:

english

Fichier:

PDF, 1.52 MB

english, 2009

Protein–protein interactions regulate Ubl conjugation

Puck Knipscheer, Titia K Sixma

Journal:

Current Opinion in Structural Biology

Année:

2007

Langue:

english

Fichier:

PDF, 2.00 MB

english, 2007

Variations on the ABC

Joyce H.G. Lebbink, Titia K. Sixma

Journal:

Structure

Année:

2005

Langue:

english

Fichier:

PDF, 236 KB

english, 2005

DNA mismatch repair: MutS structures bound to mismatches

Titia K Sixma

Journal:

Current Opinion in Structural Biology

Année:

2001

Langue:

english

Fichier:

PDF, 150 KB

english, 2001

Crystal structure of the Ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA

Luca Jovine, Tobias Hainzl, Chris Oubridge, William G Scott, Jade Li, Titia K Sixma, Alan Wonacott, Tadeusz Skarzynski, Kiyoshi Nagai

Journal:

Structure

Année:

2000

Langue:

english

Fichier:

PDF, 708 KB

english, 2000

Refined Structure of Escherichia coli Heat-labile Enterotoxin, a Close Relative of Cholera Toxin

Titia K. Sixma, Kor H. Kalk, Ben A.M. van Zanten, Zbigniew Dauter, Jaap Kingma, Bernard Witholt, Wim G.J. Hol

Journal:

Journal of Molecular Biology

Année:

1993

Fichier:

PDF, 1.97 MB

1993

X-Ray studies reveal lanthanide binding sites at the A/B5 interface of E. coli heat labile enterotoxin

Titia K. Sixma, Anke C. Terwisscha van Scheitinga, Kor H. Kalk, Kangjing Zhou, Ellen S. Wartna, Wim G.J. Hol

Journal:

FEBS Letters

Année:

1992

Langue:

english

Fichier:

PDF, 408 KB

english, 1992

Heat-labile enterotoxin crystal forms with variable A/B5 orientation Analysis of conformational flexibility

Titia K. Sixma, Angel Aguirre, Anke C.Terwisscha van Scheltinga, Ellen S. Wartna, Kor H. Kalk, Wim G.J. Hol

Journal:

FEBS Letters

Année:

1992

Langue:

english

Fichier:

PDF, 361 KB

english, 1992

Structure of partially-activated E. coli heat-labile enterotoxin (LT) at 2.6 Å resolution

Ethan A. Merritt, Sylvia E. Pronk, Titia K. Sixma, Kor H. Kalk, Ben A.M. van Zanten, Wim G.J. Hol

Journal:

FEBS Letters

Année:

1994

Langue:

english

Fichier:

PDF, 580 KB

english, 1994

A Genomic and Functional Inventory of Deubiquitinating Enzymes

Sebastian M.B. Nijman, Mark P.A. Luna-Vargas, Arno Velds, Thijn R. Brummelkamp, Annette M.G. Dirac, Titia K. Sixma, René Bernards

Journal:

Cell

Année:

2005

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2005

Symmetry and Asymmetry of the RING–RING Dimer of Rad18

Anding Huang, Richard G. Hibbert, Rob N. de Jong, Devashish Das, Titia K. Sixma, Rolf Boelens

Journal:

Journal of Molecular Biology

Année:

2011

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2011

Transient transfection coupled to baculovirus infection for rapid protein expression screening in insect cells

Stephan Radner, Patrick H.N. Celie, Karoline Fuchs, Werner Sieghart, Titia K. Sixma, Mariano Stornaiuolo

Journal:

Journal of Structural Biology

Année:

2012

Langue:

english

Fichier:

PDF, 1.22 MB

english, 2012

Ubc9 Sumoylation Regulates SUMO Target Discrimination

Puck Knipscheer, Annette Flotho, Helene Klug, Jesper V. Olsen, Willem J. van Dijk, Alexander Fish, Erica S. Johnson, Matthias Mann, Titia K. Sixma, Andrea Pichler

Journal:

Molecular Cell

Année:

2008

Langue:

english

Fichier:

PDF, 1.66 MB

english, 2008

Mechanism of USP7/HAUSP Activation by Its C-Terminal Ubiquitin-like Domain and Allosteric Regulation by GMP-Synthetase

Alex C. Faesen, Annette M.G. Dirac, Anitha Shanmugham, Huib Ovaa, Anastassis Perrakis, Titia K. Sixma

Journal:

Molecular Cell

Année:

2011

Langue:

english

Fichier:

PDF, 2.22 MB

english, 2011

The Binding Site of Acetylcholine Receptor as Visualized in the X-Ray Structure of a Complex between α-Bungarotoxin and a Mimotope Peptide

Michal Harel, Roni Kasher, Anne Nicolas, J.Mitchell Guss, Moshe Balass, Mati Fridkin, August B. Smit, Katjuša Brejc, Titia K. Sixma, Ephraim Katchalski-Katzir, Joel L. Sussman, Sara Fuchs

Journal:

Neuron

Année:

2001

Langue:

english

Fichier:

PDF, 605 KB

english, 2001

Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures

Patrick H.N Celie, Sarah E van Rossum-Fikkert, Willem J van Dijk, Katjuša Brejc, August B Smit, Titia K Sixma

Journal:

Neuron

Année:

2004

Langue:

english

Fichier:

PDF, 481 KB

english, 2004

Protein engineering: Making ubiquitin specific

Sixma, Titia K.

Journal:

Nature Chemical Biology

Année:

2012

Langue:

english

Fichier:

PDF, 419 KB

english, 2012

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

Mattiroli, Francesca, Vissers, Joseph H.A., van Dijk, Willem J., Ikpa, Pauline, Citterio, Elisabetta, Vermeulen, Wim, Marteijn, Jurgen A., Sixma, Titia K.

Journal:

Cell

Année:

2012

Langue:

english

Fichier:

PDF, 2.16 MB

english, 2012

Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein

Stornaiuolo, Mariano, De Kloe, Gerdien E., Rucktooa, Prakash, Fish, Alexander, van Elk, René, Edink, Ewald S., Bertrand, Daniel, Smit, August B., de Esch, Iwan J. P., Sixma, Titia K.

Journal:

Nature Communications

Année:

2013

Langue:

english

Fichier:

PDF, 1.85 MB

english, 2013

Use of Acetylcholine Binding Protein in the Search for Novel α7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X-ray Analysis †

Ulens, Chris, Akdemir, Atilla, Jongejan, Aldo, van Elk, Rene, Bertrand, Sonia, Perrakis, Anastassis, Leurs, Rob, Smit, August B., Sixma, Titia K., Bertrand, Daniel, de Esch, Iwan J. P.

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 1.28 MB

english, 2009

Effect of Cobratoxin Binding on the Normal Mode Vibration within Acetylcholine Binding Protein

Bertaccini, Edward J., Lindahl, Erik, Sixma, Titia, Trudell, James R.

Journal:

Journal of Chemical Information and Modeling

Année:

2008

Langue:

english

Fichier:

PDF, 1.92 MB

english, 2008

Nicking Single DNA Molecules to Study Initiation of Mismatch Repair

Monnet, Jordan, Quessada-Vial, Audrey, Hermans, Nicolaas, Graves, Evan, Winterwerp, Herrie H.K., Friedhoff, Peter, Sixma, Titia K., Lebbink, Joyce H.G., Strick, Terence R.

Journal:

Biophysical Journal

Année:

2014

Langue:

english

Fichier:

PDF, 48 KB

english, 2014